NOX4/NADPH Oxidase 4
Product Specifications
Gene Name
[NOX4]
NCBI Gene ID
50507
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.
Other Gene Names
[NOX4; NOX4; KOX; KOX-1; RENOX; RENOX; KOX-1]
Short Name
[NOX4/NADPH Oxidase 4]
Other Product Names
[NADPH oxidase 4 isoform b; NADPH oxidase 4; NADPH oxidase 4; NADPH oxidase 4; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase]
NCBI GI Number
219842346
NCBI Accession Number
NP_001137308.1
NCBI GB Accession Number
NM_001143836.2
Uniprot Accession Number
Q9NPH5
Available Sizes
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