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NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)

Product Specifications

Gene Name

[NKX2.2]

NCBI Gene ID

4821

Reactivity

Human. Others not known.

Storage Conditions

Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential small round cell tumors.

Other Gene Names

[NKX2-2; NKX2-2; NKX2B; NKX2.2; NKX2.2; NKX2B]

Short Name

[NKX2.2]

Other Product Names

[homeobox protein Nkx-2.2; Homeobox protein Nkx-2.2; homeobox protein Nkx-2.2; NK2 homeobox 2; Homeobox protein NK-2 homolog B]

NCBI GI Number

4505401

NCBI Accession Number

NP_002500.1

NCBI GB Accession Number

NM_002509.3

Uniprot Accession Number

O95096

Available Sizes

Frequently Asked Questions

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