NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)
Product Specifications
Gene Name
[NKX2.2]
NCBI Gene ID
4821
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential small round cell tumors.
Other Gene Names
[NKX2-2; NKX2-2; NKX2B; NKX2.2; NKX2.2; NKX2B]
Short Name
[NKX2.2]
Other Product Names
[homeobox protein Nkx-2.2; Homeobox protein Nkx-2.2; homeobox protein Nkx-2.2; NK2 homeobox 2; Homeobox protein NK-2 homolog B]
NCBI GI Number
4505401
NCBI Accession Number
NP_002500.1
NCBI GB Accession Number
NM_002509.3
Uniprot Accession Number
O95096
Available Sizes
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