MUC1/CA15-3/EMA/CD227 (Epithelial Marker)
Product Specifications
Gene Name
[MUC1]
NCBI Gene ID
4582
Reactivity
Human. Others not known.
Storage Conditions
Antibody without azide - store at -20 to -80 degree C. Non-hazardous. No MSDS required.
Specificity
This MAb reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of this MAb involves both amino acids as well as sugar moieties. Neuraminidase treatment destroys the antigen. It is a very good tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up-regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion.
Other Gene Names
[MUC1; MUC1; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta]
Short Name
[MUC1/CA15-3/EMA/CD227]
Other Product Names
[mucin-1 isoform 2; Mucin-1; mucin-1; mucin 1, cell surface associated; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3]
NCBI GI Number
67189007
NCBI Accession Number
NP_001018016.1
NCBI GB Accession Number
NM_001018016.2
Uniprot Accession Number
P15941
Available Sizes
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