MCM7/CDC47 (Proliferation Marker)
Product Specifications
Gene Name
[MCM7]
NCBI Gene ID
4176
Reactivity
Human. Others not known
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.
Other Gene Names
[MCM7; MCM7; MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3; CDC47; MCM2]
Short Name
[MCM7/CDC47]
Other Product Names
[DNA replication licensing factor MCM7 isoform 2; DNA replication licensing factor MCM7; DNA replication licensing factor MCM7; minichromosome maintenance complex component 7; CDC47 homolog; P1.1-MCM3]
NCBI GI Number
518830597
NCBI Accession Number
NP_001265524.1
NCBI GB Accession Number
NM_001278595.1
Uniprot Accession Number
P33993
Available Sizes
Curated Selection
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