Cytokeratin 10 (Suprabasal Epithelial Marker)
Product Specifications
Gene Name
[KRT10]
NCBI Gene ID
3858
Reactivity
Human, Dog, Cat. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Other Gene Names
[KRT10; KRT10; BIE; EHK; K10; KPP; BCIE; CK10; KPP; CK-10; K10]
Short Name
[Cytokeratin 10]
Other Product Names
[keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 10; keratin, type I cytoskeletal 10; keratin 10; Cytokeratin-10; CK-10; Keratin-10; K10]
NCBI GI Number
195972866
NCBI Accession Number
NP_000412.3
NCBI GB Accession Number
NM_000421.3
Uniprot Accession Number
P13645
Available Sizes
Curated Selection
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