Catenin, gamma (Cardiomyocyte Marker)
Product Specifications
Gene Name
[JUP]
NCBI Gene ID
3728
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (alpha, beta, gamma and delta) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimers disease (LOAD) as well as to dilated cardiomyopathy.
Other Gene Names
[JUP; JUP; DP3; PDGB; PKGB; CTNNG; DPIII; CTNNG; DP3]
Short Name
[Catenin, gamma]
Other Product Names
[junction plakoglobin; Junction plakoglobin; junction plakoglobin; junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3]
NCBI GI Number
4504811
NCBI Accession Number
NP_002221.1
NCBI GB Accession Number
NM_002230.3
Uniprot Accession Number
P14923
Available Sizes
Curated Selection
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