CD61/Integrin beta-3/Platelet Glycoprotein IIIa (Platelet Marker)
Product Specifications
Gene Name
[CD61]
NCBI Gene ID
3690
Reactivity
Human. Others not tested.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Non-hazardous. No MSDS required.
Specificity
Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alphaIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Other Gene Names
[ITGB3; ITGB3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; GP3A; GPIIIa]
Short Name
[CD61/Integrin beta-3/Platelet Glycoprotein IIIa]
Other Product Names
[integrin beta-3; Integrin beta-3; integrin beta-3; integrin subunit beta 3; Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61]
NCBI GI Number
47078292
NCBI Accession Number
NP_000203.2
NCBI GB Accession Number
NM_000212.2
Uniprot Accession Number
P05106
Available Sizes
Curated Selection
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