6-Methoxy-4-methylcoumarin

6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo[1].

Product Specifications

CAS Number

[6295-35-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3; Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6-methoxy-4-methylcoumarin.html

Purity

99.00

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC(=O)OC2=C1C=C(C=C2)OC

Molecular Formula

C11H10O3

Molecular Weight

190.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee YJ, et al. Mechanistic Insights into the Stimulatory Effect of Melanogenesis of 4-Methylcoumarin Derivatives in B16F10 Melanoma Cells. Int J Mol Sci. 2024 Nov 19;25 (22) :12421.