IGS-1.76

IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1].

Product Specifications

CAS Number

[313480-47-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/igs-1-76.html

Concentration

10mM

Purity

98.57

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC2=CC=CC=C2S1)CC(C3=CC=CC=C3)C4=CC=CC=C4

Molecular Formula

C22H18N2OS

Molecular Weight

358.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61 (14) :5910-5921.