Butamben-d9

Butamben-d9 is the deuterium labeled Butamben. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions[1][2].

Product Specifications

Product Name Alternative

Butyl 4-aminobenzoate-d9

UNSPSC

12352005

Target

Calcium Channel; Isotope-Labeled Compounds; Potassium Channel; Sodium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C1=CC=C(N)C=C1

Molecular Formula

C11H6D9NO2

Molecular Weight

202.30

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Berg RJV, et, al. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Anesthesiology. 1995 Jun;82 (6) :1463-73.|[3]Rampaart LJA, et, al. The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells. Anesth Analg. 2008 Jun;106 (6) :1778-83.|[4]Cereda CM, et al. Liposomal butamben gel formulations: toxicity assays and topical anesthesia in an animal model. J Liposome Res. 2017 Mar;27 (1) :74-82.