(p-Iodo-Phe7) -ACTH (4-10)
(p-Iodo-Phe7) -ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7) -ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH) -induced excessive grooming behavior in rats[1].
Product Specifications
CAS Number
159600-82-5
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-iodo-phe7-acth-4-10.html
Solubility
10 mM in DMSO
Smiles
IC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](N)CCSC)=O)=O)CC2=CN=CN2)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O
Molecular Formula
C44H58IN13O10S
Molecular Weight
1087.98
References & Citations
[1]Adan RA, et al. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. Eur J Pharmacol. 1994 Nov 15;269 (3) :331-7. |[2]Schiöth HB, et al. Selectivity of [Phe-I7], [Ala6], and [D-Ala4, Gln5, Tyr6] substituted ACTH (4-10) analogues for the melanocortin receptors. Peptides. 1997;18 (5) :761-3.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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