NE58018
NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS) . The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme[1].
Product Specifications
CAS Number
105462-23-5
UNSPSC
12352005
Hazard Statement
H317-H334
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ne58018.html
Smiles
OC([P](O)(O)=O)([P](O)(O)=O)CC1=CC=CC=N1
Molecular Formula
C7H11NO7P2
Molecular Weight
283.11
Precautions
P261-P272-P280-P284-P302+P352-P304+P340-P362+P364-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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