3-Methyladenine
3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[1].
Product Specifications
CAS Number
5142-23-4
Product Name Alternative
3-MA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Endogenous Metabolite; Mitophagy; PI3K
Type
Natural Products
Related Pathways
Autophagy; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-Methyladenine.html
Purity
99.91
Solubility
DMSO : 8.33 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
NC1=C2N=CN=C2N(C)C=N1
Molecular Formula
C6H7N5
Molecular Weight
149.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6 (6) :805-7.|[2]Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7 (4) :e35665.|[3]Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 2016;2016:8369704.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; PI3Kγ; Vps34
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