LCL521
LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) [1].
Product Specifications
CAS Number
1226851-11-1
UNSPSC
12352005
Hazard Statement
H225, H350
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LCL521.html
Concentration
10mM
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CN(C)C)O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@@H](COC(CN(C)C)=O)NC(CCCCCCCCCCCCC)=O
Molecular Formula
C31H52N4O7
Molecular Weight
592.77
Precautions
H225, H350
References & Citations
[1]Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22 (24) :6933-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Nat Immunol. 2023 May;24 (5) :802-813.|Hum Mol Genet. 2025 Nov 13.
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