Human NRG1 Beta1 Protein

Human NRG1 Beta1 Protein, expressed in E. coli

Product Specifications

Background

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44 kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

Product Name Alternative

ARIA; NRG1; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

Gene ID

142445

Accession Number

Q02297

Tag

No-tag

Type

Cytokines and proteins

Applications

No tag

Purity

> 99 % as determined by SDS-PAGE

Activity

Measured by its ability to induce proliferation in MCF-7 cells. The ED50 for this effect is 0.6730 ng/mL.

Molecular Weight

24.04 kDa

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Features & Benefits

Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.

Shipping Conditions

The product is shipped at ambient temperature.

Storage Conditions

Lyophilized Recombinant Human NRG1 Beta1 Protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles

Protein Length

The Recombinant Human NRG1 Beta1 Protein consists of 220 amino acids and predicts a molecular mass of 24.04KDa

Formulation

Lyophilized from sterile 20 mM Tris with 150 mM NaCl, pH 7.4

Applications Notes

Human

Other Product Names

ARIA; NRG1; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

Recommended Usage

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously