Diazo Biotin-PEG3-azide

Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Diazo Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1339202-33-3]

UNSPSC

12352005

Hazard Statement

H240

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/diazo-biotin-peg3-azide.html

Purity

95.46

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NCCOCCOCCOCCNC(C1=CC=C(/N=N/C2=CC(CCN=[N+]=[N-])=CC=C2O)C=C1)=O)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O

Molecular Formula

C33H45N9O7S

Molecular Weight

711.83

Precautions

P210-P234-P235-P240-P280-P370+P372+P380+P373-P403-P410-P420-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562