Human B7-H6 / NCR3LG1 Protein, His Tag (MALS verified)

The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.6 kDa. The protein migrates as 38-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Immobilized Human NKp30, Fc Tag (Cat. No. NC3-H5259) at 10 μg/mL (100 μL/well) can bind Human B7-H6 Protein, His Tag (Cat. No. B76-H52H8) with a linear range of 0.016-0.25 μg/mL (QC tested).