Human Prothrombin Complex

<strong>Human Prothrombin Complex</strong>_x000D_ <strong>Catalog number:</strong> B2012314_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 IU_x000D_ <strong>Molecular Weight or Concentration:</strong> NA_x000D_ <strong>Supplied as:</strong> Lyophilized_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> PCC_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Nederpelt CJ, Naar L, Krijnen P, le Cessie S, Kaafarani HMA, Huisman MV, Velmahos GC, Schipper IB. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis Crit Care Med. 2021 Oct 1;49(10):e1025-e1036._x000D_ 2: N Engl J Med. 1965 Sep 23;273(13):715-6. doi: 10.1056/NEJM196509232731311. Human prothrombin complex N Engl J Med_x000D_ 3: Schwebach AA, Waybright RA, Johnson TJ. Fixed-Dose Four-Factor Prothrombin Complex Concentrate for Vitamin K Antagonist Reversal: Does One Dose Fit All? Pharmacotherapy. 2019 May;39(5):599-608._x000D_ 4: Stevens VM, Trujillo TC, Kiser TH, MacLaren R, Reynolds PM, Mueller SW. Retrospective Comparison of Andexanet Alfa and 4-Factor Prothrombin Complex for Reversal of Factor Xa-Inhibitor Related Bleeding Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211039020._x000D_ 5: Bertolaccini ML. Antibodies to prothrombin Lupus. 2012 Jun;21(7):729-31._x000D_ 6: Kamihara Y, Kikuchi S, Wada A, Murakami J, Sugie N, Niimi H, Nakashima A, Sato T. [Successful preoperative replacement of prothrombin with prothrombin complex concentrate for Prothrombin Himi] Rinsho Ketsueki. 2021;62(9):1412-1414._x000D_ 7: Green D. Pathophysiology of Antiphospholipid Syndrome Thromb Haemost. 2022 Jul;122(7):1085-1095._x000D_ 8: DeWitt RT, Feinstein DI. Prothrombin complex concentrate Arch Intern Med. 1977 Sep;137(9):1211-3._x000D_ 9: Eltringham-Smith LJ, Yu R, Qadri SM, Wang Y, Bhakta V, Pryzdial EL, Crosby JR, Ni H, Sheffield WP. Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy Thromb Haemost. 1991 Dec 2;66(6):629-32._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/1796407">10: Bevers EM, Galli M, Barbui T, Comfurius P, Zwaal RF. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin Thromb Haemost. 1991 Dec 2;66(6):629-32.</a>_x000D_ _x000D_ <strong>Products Related to Human Prothrombin Complex can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>