β-Naphthoflavone
Product Specifications
Product Name Alternative
GMX1777; EB-1627
UNSPSC Description
β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury[1][2][3].
Target Antigen
Apoptosis; Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-naphthoflavone.html
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1C2=C3C=CC=CC3=CC=C2OC(C4=CC=CC=C4)=C1
Molecular Weight
272.303
References & Citations
[1]Ishida T, Takechi S. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44(10):711-720.|[2]Zhu Y, et al. α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med. 2017 Mar;13(3):1143-1150. |[3]Ying Xiao, et al. β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacologica Sinica 30.11 (2009): 1559-1565.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114740/β-Naphthoflavone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114740/β-Naphthoflavone-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
6051-87-2
Available Sizes
Curated Selection
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