Phentolamine (mesylate)

Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].

Product Specifications

CAS Number

[65-28-1]

Product Name Alternative

Phentolamine methanesulfonate

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/phentolamine-mesylate.html

Purity

99.90

Solubility

H2O : ≥ 50 mg/mL

Smiles

CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1

Molecular Formula

C18H23N3O4S

Molecular Weight

377.46

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Gould L, et, al. Phentolamine. Am Heart J. 1976 Sep;92 (3) :397-402.|[2]Goldstein I, et, al. Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res. 2000 Mar;12 Suppl 1:S75-80.|[3]Liu L, et, al. Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br J Pharmacol. 1996 Mar;117 (5) :787-92.|[4]Pan L, et, al. Phentolamine inhibits angiogenesis in vitro: Suppression of proliferation migration and differentiation of human endothelial cells. Clin Hemorheol Microcirc. 2017;65 (1) :31-41.|[5]Fioretti AC, et, al. Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul Pharmacol. 2017 Dec;99:53-64.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

α adrenergic receptor

Citation 01

BioRxiv. 2023 Oct 13.|J Endocrinol. 2020 Mar;244 (3) :459-471.|Insect Biochem Mol Biol. 2025 May:180:104312.|J Cancer. 2024 Sep 9;15 (17) :5691-5709.|Neurosci Bull. 2023 Dec;39 (12) :1789-1806.