Ancitabine (hydrochloride)

Ancitabine hydrochloride is the precursor of the anticancer agent Cytarabine (HY-13605), which targets targets related to cell metabolism and proliferation. Ancitabine hydrochloride can inhibit tumor cell proliferation, interfere with the DNA synthesis process of tumor cells, and prevent cell division. Under alkaline pH conditions, Ancitabine hydrochloride can be quantitatively converted into Cytarabine and can be used in the study of cancers such as colorectal cancer[1][2].

Product Specifications

CAS Number

[10212-25-6]

Product Name Alternative

Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; CMV; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Ancitabine-hydrochloride.html

Purity

99.83

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

OC[C@@H]1[C@@H](O)[C@H](OC2=N3)[C@H](N2C=CC3=N)O1.[H]Cl

Molecular Formula

C9H12ClN3O4

Molecular Weight

261.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Aftab O, et al. Detection of cell aggregation and altered cell viability by automated label-free video microscopy: a promising alternative to endpoint viability assays in high-throughput screening. J Biomol Screen. 2015 Mar;20 (3) :372-81.|[2]Kirsch LE, et al. Aqueous conversion kinetics and mechanisms of ancitabine, a prodrug of the antileukemic agent cytarabine. J Pharm Sci. 1984 Jul;73 (7) :896-902.