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(E/Z) -BML264

(E/Z) -BML264 (N- (p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. (E/Z) -BML264 (N- (p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].

Product Specifications

CAS Number

110683-10-8

Product Name Alternative

N- (p-Amylcinnamoyl) anthranilic acid; ACA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phospholipase; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e-z-bml264.html

Purity

99.63

Solubility

DMSO : 233.33 mg/mL (ultrasonic)

Smiles

CCCCCC1=CC=C(C=C1)/C=C/C(NC2=CC=CC=C2C(O)=O)=O

Molecular Formula

C21H23NO3

Molecular Weight

337.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Kraft R, et al. Inhibition of TRPM2 cation channels by N- (p-amylcinnamoyl) anthranilic acid. Br J Pharmacol. 2006 Jun;148 (3) :264-73.|[2]Harteneck C, et al. N- (p-amylcinnamoyl) anthranilic acid (ACA) : a phospholipase A (2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25 (1) :61-75.|[3]Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N- (p-amylcinnamoyl) anthranilic acid (ACA) . Biochem Biophys Res Commun. 2010 Nov 19;402 (3) :531-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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