(E/Z)-BML264
Product Specifications
Product Name Alternative
MK-0822
UNSPSC Description
(E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].
Target Antigen
Phospholipase; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/e-z-bml264.html
Purity
99.63
Solubility
DMSO : 233.33 mg/mL (ultrasonic)
Smiles
CCCCCC1=CC=C(C=C1)/C=C/C(NC2=CC=CC=C2C(O)=O)=O
Molecular Weight
337.41
References & Citations
[1]Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.|[2]Harteneck C, et al. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75.|[3]Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118628/E-Z-BML264-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118628/E-Z-BML264-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
110683-10-8
Available Sizes
Curated Selection
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