Ogerin

Ogerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM) . Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders[1][2].

Product Specifications

CAS Number

[1309198-71-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

GPR68

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ogerin.html

Purity

99.9400

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCC1=C(C2=NC(N)=NC(NCC3=CC=CC=C3)=N2)C=CC=C1

Molecular Formula

C17H17N5O

Molecular Weight

307.35

Precautions

H315, H319, H320

References & Citations

[1]Bell TJ, et al. Ogerin mediated inhibition of TGF-β (1) induced myofibroblast differentiation is potentiated by acidic pH. PLoS One. 2022 Jul 28;17 (7) :e0271608. |[2]Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527 (7579) :477-83.