Ogerin
Ogerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM) . Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders[1][2].
Product Specifications
CAS Number
1309198-71-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
GPR68
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ogerin.html
Purity
99.9400
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OCC1=C(C2=NC(N)=NC(NCC3=CC=CC=C3)=N2)C=CC=C1
Molecular Formula
C17H17N5O
Molecular Weight
307.35
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
VDAC1 (mVDAC5, OMP2, outer Mitochondrial Membrane Protein porin 1, plasmalemmal porin, porin 31HL, porin 31HM, PORIN, VDAC 5, Voltage-Dependent Anion-selective Channel Protein 1) discontinued
VDAC1 (mVDAC5, OMP2, outer Mitochondrial Membrane Protein porin 1, plasmalemmal porin, porin 31HL, porin 31HM, PORIN, VDAC 5, Voltage-Dependent Anion-selective Channel Protein 1) discontinued
LYK5 (STRADA) (NM_001165969) Human Tagged Lenti ORF Clone
