Tricin-d6
Tricin-d6 is the deuterium labeled Tricin[1]. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK) -targeting microRNA-7[2][3][4].
Product Specifications
UNSPSC
12352005
Target
CMV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(OC([2H])([2H])[2H])=C(C(OC([2H])([2H])[2H])=C3)O)=C1
Molecular Formula
C17H8D6O7
Molecular Weight
336.33
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Itoh A, et al. Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus. Microbiol Immunol. 2018 May;62 (5) :341-347.|[3]Sadanari H, et al. The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. FEBS Open Bio. 2018 Feb 208 (4) :646-654.|[4]Chung DJ, et al. Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7. J Agric Food Chem. 2018 Jul 566 (26) :6708-6716.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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