Tricin-d6

Tricin-d6 is the deuterium labeled Tricin[1]. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK) -targeting microRNA-7[2][3][4].

Product Specifications

UNSPSC

12352005

Target

CMV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(OC([2H])([2H])[2H])=C(C(OC([2H])([2H])[2H])=C3)O)=C1

Molecular Formula

C17H8D6O7

Molecular Weight

336.33

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Itoh A, et al. Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus. Microbiol Immunol. 2018 May;62 (5) :341-347.|[3]Sadanari H, et al. The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. FEBS Open Bio. 2018 Feb 208 (4) :646-654.|[4]Chung DJ, et al. Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7. J Agric Food Chem. 2018 Jul 566 (26) :6708-6716.