Multi-kinase inhibitor 4
Multi-kinase inhibitor 4 (compound 14) is an orally active inhibitor of FLT1, KDR, FLT3, FLT4, PDGFRα, PDGFRβ, with IC50s of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, 0.89 nM. Multi-kinase inhibitor 4 plays an important role in cancer research[1].
Product Specifications
CAS Number
2648279-77-8
UNSPSC
12352005
Target
FLT3; PDGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/multi-kinase-inhibitor-4.html
Smiles
O=C(NC1=CC(C(C)(C)C)=NO1)CC(C=C2)=CC=C2N3C4=CC=C(C5=CNN=C5)C=C4N=C3
Molecular Formula
C25H24N6O2
Molecular Weight
440.50
References & Citations
[1]Debasis Das, et al. Discovery of novel, orally bioavailable phenylacetamide derivatives as multikinase inhibitors and in vivo efficacy study in hepatocellular carcinoma animal models. Bioorg Med Chem Lett. 2024 Sep 19:113:129971. |[2]Debasis Das, et al. Discovery of novel, orally bioavailable phenylacetamide derivatives as multikinase inhibitors and in vivo efficacy study in hepatocellular carcinoma animal models. Bioorg Med Chem Lett. 2024 Sep 19:113:129971.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRα; PDGFRβ
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