Procarbazine (Hydrochloride)

Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research[1][2].

Product Specifications

CAS Number

[366-70-1]

UNSPSC

12352005

Hazard Statement

H302, H341, H350, H360

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Procarbazine-Hydrochloride.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NC(C)C)C1=CC=C(CNNC)C=C1.Cl

Molecular Formula

C12H20ClN3O

Molecular Weight

257.76

Precautions

H302, H341, H350, H360

References & Citations

[1]J M Erikson, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49 (1) :127-33.|[2]T Suzuki, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444 (2) :269-81.