AACOCF3
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2) . AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease[1][2][3].
Product Specifications
CAS Number
149301-79-1
Product Name Alternative
Arachidonyl trifluoromethyl ketone
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aacocf3.html
Concentration
28.05 mM * 1 mL in Ethanol
Purity
99.89
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(C(F)(F)F)=O
Molecular Formula
C21H31F3O
Molecular Weight
356.47
Precautions
H225, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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