HABP2 (50k heavy chain, Cleaved-Arg313) rabbit pAb

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],

Product Specifications

Background

UniProt

Q14520

Swiss Prot

Q14520

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human HABP2 (50k heavy chain, Cleaved-Arg313)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight

50 77kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

50 77kD

Fragment

IgG

Subcellular Location

Secreted . Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Other Product Names

Hyaluronan-binding protein 2 (EC 3.4.21.-; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]