Benzoylmesaconine
Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress NLRP3 inflammasome activation by inhibiting IL-1β secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K+ efflux and disrupts NLRP3 inflammasome assembly[1][2][3].
Product Specifications
CAS Number
63238-67-5
Product Name Alternative
Mesaconine 14-benzoate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Interleukin Related; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Benzoylmesaconine.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CO[C@@H]1C2([C@@](C[C@@]3(O)[C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]4([H])[C@](O)([C@@H](O)[C@@H]3OC)C6C2N(C)C7)[C@@]([C@H]6OC)([H])[C@@]7(COC)[C@H](O)C1
Molecular Formula
C31H43NO10
Molecular Weight
589.67
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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