Benzoylmesaconine

Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress NLRP3 inflammasome activation by inhibiting IL-1β secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K+ efflux and disrupts NLRP3 inflammasome assembly[1][2][3].

Product Specifications

CAS Number

[63238-67-5]

Product Name Alternative

Mesaconine 14-benzoate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Interleukin Related; NF-κB

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Benzoylmesaconine.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CO[C@@H]1C2([C@@](C[C@@]3(O)[C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]4([H])[C@](O)([C@@H](O)[C@@H]3OC)C6C2N(C)C7)[C@@]([C@H]6OC)([H])[C@@]7(COC)[C@H](O)C1

Molecular Formula

C31H43NO10

Molecular Weight

589.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Dai PM, et al. Pharmacokinetic comparisons of benzoylmesaconine in rats using ultra-performance liquid chromatography-tandem mass spectrometry after administration of pure benzoylmesaconine and Wutou decoction. Molecules. 2014 Oct 17;19 (10) :16757-69.|[2]Ye L, et al. Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5. Evid Based Complement Alternat Med. 2013;2013:941093.|[3]Zhang, Z., et al., (2024) . Benzoylmesaconine mitigates NLRP3 inflammasome-related diseases by reducing intracellular K+ efflux and disrupting NLRP3 inflammasome assembly. Phytomedicine : international journal of phytotherapy and phytopharmacology, 135, 156154.