Meclizine (dihydrochloride monohydrate)
Meclizine (Meclozine) dihydrochloride monohydrate, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride monohydrate is an effective anti-motion sickness agent. Meclizine dihydrochloride monohydrate crosses the blood-brain barrier. Meclizine dihydrochloride monohydrate is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine dihydrochloride monohydrate can be used for the research of polyQ toxicity disorders, such as Huntington's disease[1][2][3].
Product Specifications
CAS Number
31884-77-2
Product Name Alternative
Meclozine (dihydrochloride monohydrate)
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Histamine Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/meclizine-dihydrochloride-monohydrate.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1.[H]Cl.[H]Cl.O
Molecular Formula
C25H31Cl3N2O
Molecular Weight
481.89
Precautions
P264-P270-P330-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Frequently Asked Questions
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