Meclizine (dihydrochloride monohydrate)

Meclizine (Meclozine) dihydrochloride monohydrate, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride monohydrate is an effective anti-motion sickness agent. Meclizine dihydrochloride monohydrate crosses the blood-brain barrier. Meclizine dihydrochloride monohydrate is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine dihydrochloride monohydrate can be used for the research of polyQ toxicity disorders, such as Huntington's disease[1][2][3].

Product Specifications

CAS Number

[31884-77-2]

Product Name Alternative

Meclozine (dihydrochloride monohydrate)

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Histamine Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/meclizine-dihydrochloride-monohydrate.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1.[H]Cl.[H]Cl.O

Molecular Formula

C25H31Cl3N2O

Molecular Weight

481.89

Precautions

P264-P270-P330-P501

References & Citations

[1]Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.|[2]Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20 (2) :294-300.|[3]Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2 (9) :1090-101.|[4]Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR