KH-3

KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction[1].

Product Specifications

CAS Number

[1215115-03-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HuR

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kh-3.html

Purity

98.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NO)/C=C/C1=CC2=CC(NS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)=CC=C2S1

Molecular Formula

C21H22N2O4S2

Molecular Weight

430.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu X, et, al. Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Commun Biol. 2020 Apr 24;3 (1) :193.