L-Tryptophan

L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels[1][2][3].

Product Specifications

CAS Number

[73-22-3]

Product Name Alternative

Tryptophan; Tryptophane

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/L-Tryptophan.html

Purity

99.99

Solubility

DMSO : 7.69 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O

Molecular Formula

C11H12N2O2

Molecular Weight

204.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Slominski A, et al. Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett. 2002 Jan 30;511 (1-3) :102-6.|[2]Kang Xu, et al. L-Tryptophan activates the aryl hydrocarbon receptor and induces cell cycle arrest in porcine trophectoderm cells. Theriogenology. 2021 Sep 1:171:137-146.|[3]Hai Thanh Pham, et al. Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo. Materials (Basel) . 2021 Jan 4;14 (1) :208.