Liafensine

Liafensine (BMS-820836) is a triple monoamine reuptake inhibitor (TRI), that inhibits dopamine transporter, serotonin transporter and norepinephrine transporter, with IC50s of 5.67, 1.08 and 7.99 nM, respectively. Liafensine exhibits antidepressant activity[1].

Product Specifications

CAS Number

[1198790-53-2]

Product Name Alternative

BMS-820836

UNSPSC

12352005

Target

Dopamine Transporter; Monoamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/liafensine.html

Purity

99.46

Smiles

NC1=NN=C(C2=CC3=C(C=C2)[C@H](C4=CC=C5C=CC=CC5=C4)CN(C)C3)C=C1

Molecular Formula

C24H22N4

Molecular Weight

366.46

References & Citations

[1]Risinger R, et al., Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study. Psychopharmacology (Berl) . 2014 Jun;231 (11) :2299-310.