BCX 1470 (methanesulfonate)

BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

Product Specifications

CAS Number

[217099-44-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Complement System

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bcx-1470-methanesulfonate.html

Purity

99.87

Solubility

DMSO : ≥ 33.33 mg/mL

Smiles

N=C(C1=CC2=CC=C(OC(C3=CC=CS3)=O)C=C2S1)N.O=S(O)(C)=O

Molecular Formula

C15H14N2O5S3

Molecular Weight

398.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Szalai AJ, et al. The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164 (1) :463-8.|[2]Szalai AJ, et al. The Arthus reaction in rodents: species-specific requirement of complement. J Immunol. 2000 Jan 1;164 (1) :463-8.