Bamocaftor
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor and Ivacaftor (HY-13017) in cystic fibrosis research[1].
Product Specifications
CAS Number
2204245-48-5
Product Name Alternative
VX-659
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/bamocaftor.html
Concentration
10mM
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(N2N=C(OCCC3(C(F)(F)F)CC3)C=C2)N=C1N4C(C)(C)C[C@H](C)C4)NS(=O)(C5=CC=CC=C5)=O
Molecular Formula
C28H32F3N5O4S
Molecular Weight
591.64
References & Citations
[1]Ghelani DP, et al. Emerging Cystic Fibrosis Transmembrane Conductance Regulator Modulators as New Drugs for Cystic Fibrosis: A Portrait of in Vitro Pharmacology and Clinical Translation.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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