Ginsenoside Rg6

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

Product Specifications

CAS Number

[147419-93-0]

UNSPSC

12352005

Target

Apoptosis; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Ginsenoside-Rg6.html

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@@H](C(CC/C=C(C)/C)=C)CC6)C

Molecular Formula

C42H70O12

Molecular Weight

767.00

References & Citations

[1]Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul) . 2014 Jan;22 (1) :55-61.|[2]Chen B, et al. Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells. Molecules. 2013 Jul 9;18 (7) :8109-19.