Medronic acid

Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has an affinity for the surface of hydroxyapatite crystals in the bone matrix and adheres to them. Medronic acid can be used in complex with radioisotopes in bone imaging. Due to its strong metal chelating ability, medronic acid is also used as a water treatment chemical. In addition, medronic acid is used as a solvent additive to improve peak shape and signal of metal-sensitive metabolites in LC/MS analysis[1][2].

Product Specifications

CAS Number

[1984-15-2]

Product Name Alternative

Methylenediphosphonic acid

UNSPSC

12352211

Hazard Statement

H314

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Medronic_acid.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=P(O)(O)CP(O)(O)=O

Molecular Formula

CH6O6P2

Molecular Weight

176.00

Precautions

H314

References & Citations

[1]Ohta Y, et al. Salt Tolerance Enhancement of Liquid Chromatography-Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Using Matrix Additive MethylenediphosphonicAcid. Mass Spectrom (Tokyo) . 2014;3 (1) :A0031.|[2]Lin Y T, et al. Using an In-Sample Addition of Medronic Acid for the Analysis of Purine-and Pyrimidine-Related Derivatives and Its Application in the Study of Lung Adenocarcinoma A549 Cell Lines by LC–MS/MS[J]. Journal of Proteome Research, 2023, 22 (5) : 1434-1445.