Fitusiran

Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia[1].

Product Specifications

CAS Number

[1499251-18-1]

Product Name Alternative

ALN-AT3SC; SAR439774

UNSPSC

12352208

Target

Factor Xa; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fitusiran.html

Purity

94.74

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[Fitusiran]

Molecular Formula

C520H679F21N175O309P43S6

Molecular Weight

16248.2 (AS: 7675 + SS: 8573.2)

References & Citations

[1]Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort. J Thromb Haemost. 2021;19 (6) :1436-1446.