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(Rac) -NPD6433

(Rac) -NPD6433 is a racemate of NPD6433. NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis[1].

Product Specifications

CAS Number

895908-81-3

UNSPSC

12352005

Target

Fatty Acid Synthase (FASN) ; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rac-npd6433.html

Smiles

O=C(C1=C(/N=N/N2CC3C4=CC=CC(N4CC(C3)C2)=O)C5=C(C=CC=C5)N1)OC

Molecular Formula

C21H21N5O3

Molecular Weight

391.42

References & Citations

[1]Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chem Biol. 2023 Jul 20;30 (7) :795-810.e8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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