(Rac) -NPD6433
(Rac) -NPD6433 is a racemate of NPD6433. NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis[1].
Product Specifications
CAS Number
895908-81-3
UNSPSC
12352005
Target
Fatty Acid Synthase (FASN) ; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rac-npd6433.html
Smiles
O=C(C1=C(/N=N/N2CC3C4=CC=CC(N4CC(C3)C2)=O)C5=C(C=CC=C5)N1)OC
Molecular Formula
C21H21N5O3
Molecular Weight
391.42
References & Citations
[1]Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chem Biol. 2023 Jul 20;30 (7) :795-810.e8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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