Human LAG-3 / CD223 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

Product Specifications

Background

Specifications

This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 74.0 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P18627-1

Expression Region

Leu 23 - Leu 450

Host

HEK293

Target

LAG-3

Conjugation

Unconjugated

Tag

C-LlamaFc (LlamaIgG2b)

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.01 EU per μg

Purity

95%

Bioactivity

Immobilized Human LAG-3, Llama IgG2b Fc Tag (Cat. No. LA3-H525c) at 2 μg/mL (100 μL/well) can bind Anti-Human LAG3 MAb with a linear range of 0.2-4 ng/mL (QC tested).