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ASM-IN-2

ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC50 value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs[1].

Product Specifications

CAS Number

2305789-66-4

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/asm-in-2.html

Smiles

O=C(C1=NN(C(C2=CC=C(C=C2)Br)=C1)C3=CC=C(C=C3)Cl)NO

Molecular Formula

C16H11BrClN3O2

Molecular Weight

392.63

References & Citations

[1]Shi S, et al. Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action[J]. J Med Chem. 2024 Jun 18:1520-4804.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Phospholipase C

Frequently Asked Questions

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