CGAS rabbit pAb

Nucleus . Chromosome . Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964) . On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988) . Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424) . Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) (PubMed:30827685) . Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685) . Following detection of double-st