CGAS rabbit pAb
Product Specifications
UniProt
Q8N884
Swiss Prot
Q8N884
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human M21D1 AA range: 35-85
Target
M21D1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964) . On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988) . Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424) . Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) (PubMed:30827685) . Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685) . Following detection of double-st
Gene ID (Human)
115004
Available Sizes
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