Isotretinoin

Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity[1][2].

Product Specifications

CAS Number

[4759-48-2]

Product Name Alternative

13-cis-Retinoic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Autophagy; Endogenous Metabolite; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Isotretinoin.html

Purity

99.90

Solubility

DMSO : 140 mg/mL (ultrasonic)

Smiles

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C\C(O)=O)=C(C)CCC1

Molecular Formula

C20H28O2

Molecular Weight

300.44

Precautions

H315, H319, H335

References & Citations

[1]Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1 (3) :162-9.|[2]Dahl AR, et al. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6 (8) :3015-24|[3]Bergoli RD, et al. Isotretinoin effect on alveolar repair after exodontia--a study in rats. Oral Maxillofac Surg. 2011 Jun;15 (2) :85-92.|[4]Ramírez-Flores PN, et al. Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells. Molecules. 2021 Sep 22;26 (19) :5742.