Ferroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) is a specific inhibitor for ferroptosis with an EC50 of 0.7 nM and 0.9 nM in ES-2 cell and LX-2 cell. Ferroptosis-IN-16 ameliorates Acetaminophen (HY-66005) -induced acute liver injury in mouse model, and exhibits good metabolic stability in mouse liver microsomes[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ferroptosis-in-16.html
Smiles
C12=CC=CC=C1N=C3C(C=CC=C3C4=NC(C5=CC=CC(CN6CCCCC6)=C5)=NO4)=N2
Molecular Formula
C26H23N5O
Molecular Weight
421.49
References & Citations
[1]Wu Y, et al., Discovery of phenazine derivatives as a new class of non-classical ferroptosis inhibitors and efficacy evaluation on a mouse model of liver injury. Eur J Med Chem. 2025 Jan 15;282:117042.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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