Ferroptosis-IN-16

Ferroptosis-IN-16 (Compound 13l) is a specific inhibitor for ferroptosis with an EC50 of 0.7 nM and 0.9 nM in ES-2 cell and LX-2 cell. Ferroptosis-IN-16 ameliorates Acetaminophen (HY-66005) -induced acute liver injury in mouse model, and exhibits good metabolic stability in mouse liver microsomes[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ferroptosis-in-16.html

Smiles

C12=CC=CC=C1N=C3C(C=CC=C3C4=NC(C5=CC=CC(CN6CCCCC6)=C5)=NO4)=N2

Molecular Formula

C26H23N5O

Molecular Weight

421.49

References & Citations

[1]Wu Y, et al., Discovery of phenazine derivatives as a new class of non-classical ferroptosis inhibitors and efficacy evaluation on a mouse model of liver injury. Eur J Med Chem. 2025 Jan 15;282:117042.